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Filtered Search Results
Medchemexpress LLC Trifarotene | 895542-09-3 | MFCD30481310 | 99.1% | 459.58 g/mol | C29H33NO4 | 5 MG
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Trifarotene is a potent, selective retinoic acid receptor gamma (RARγ) agonist supplied as a solid for research use. It shows strong selectivity for RARγ versus RARα and RARβ, and is provided with supporting documentation for quality and safety.
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eMolecules 1234015-58-7 | Medchem Express | Prexasertib (dimesylate) | 5mg | 532149393 | HY-18174E | 557.6 | C20H27N7O8S2
ChemScene | tert-Butyl (4-chlorothiazol-2-yl)carbamate | 100mg | 536809612 | CS-0113925 | 1373223-09-6 | MFCD22201202 | 234.700 | C8H11ClN2O2S
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eMolecules 31036-80-3 | Medchem Express | Lofexidine | 50mg | 446276372 | HY-B1052A | MFCD00865915 | 259.13 | C11H12Cl2N2O
ChemScene | 35-Dimethylisonicotinonitrile | 100mg | 632276495 | CS-0033869 | 7584-08-9 | MFCD11052634 | 132.166 | C8H8N2
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Medchemexpress LLC Phenoxybenzamine hydrochloride | 63-92-3 | 99.5% | 25 MG
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Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist commonly used for hypertension research, particularly for pheochromocytoma. It also demonstrates antitumor activity.
- Inhibits U251 and U87MG cell proliferation.
- Inhibits migration and invasion of U251 and U87MG cells.
- Activates LINGO-1 and inhibits the TrkB-Akt pathway.
- Prevents hippocampal cell death after oxygen glucose deprivation.
- Shows anti-tumorigenic effect in nude mice with U87MG tumors.
- Neuroprotective in a rat model of severe traumatic brain injury.
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MEDCHEMEXPRESS LLC CINOCTRAMIDE 10MG
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501874346 CINOCTRAMIDE 10MG
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Sigma Aldrich Fine Chemicals Biosciences TPPU >=98% (HPLC) | 1222780-33-7 | 25MG
TPPU >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 359.34 | 1222780-33-7 | 25MG
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Medchemexpress LLC KRAS G12C inhibitor 15 | 2349393-21-9 | 98.5% | 498.91 g/mol | C25H21ClF2N4O3 | 100MG
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KRAS G12C inhibitor 15 is a research-grade small-molecule inhibitor selective for the KRAS G12C mutant, derived from patent WO2019110751A1 (compound 22). It is reported to inhibit KRAS G12C with an IC50 of 5 nM and is supplied as a solid for laboratory research use only.
- Potent KRAS G12C inhibition (IC50 5 nM).
- High purity (~98.5%).
- Molecular weight 498.91 g/mol; formula C25H21ClF2N4O3.
- White to yellow solid suitable for biochemical and cellular assays.
- Supplied as 100 MG for research use only.
- Derived from patent WO2019110751A1 (compound 22).
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![Medchemexpress LLC β-[4-([4-methyl-2-(4-(trifluoromethyl)phenyl)-5-thiazolyl]methoxy)phenyl]-3-isoxazolepropanoic acid | 1011531-27-3 | 99.0% | 488.48 | C24H19F3N2O4S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238246.png-250.jpg)
Medchemexpress LLC β-[4-([4-methyl-2-(4-(trifluoromethyl)phenyl)-5-thiazolyl]methoxy)phenyl]-3-isoxazolepropanoic acid | 1011531-27-3 | 99.0% | 488.48 | C24H19F3N2O4S | 10MG
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AM-4668 is a research-grade small-molecule agonist of GPR40 (FFAR1) used in preclinical studies relevant to type 2 diabetes. It activates human GPR40 with low-nanomolar potency in cell-based functional assays and is supplied as a solid for in vitro pharmacology and biochemical studies.
- Low-nanomolar potency at GPR40 (EC50 3.6 nM in A9 cells, 36 nM in CHO cells).
- Suitable for in vitro receptor activation and pharmacology studies.
- High purity solid (99.0%).
- Molecular weight 488.48 and formula C24H19F3N2O4S.
- Available in milligram quantities for laboratory use.
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Apexbio Technology LLC JW 55 664993-53-7 10mg
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JW 55 (CAS 664993-53-7) is a small-molecule inhibitor that targets the poly(ADP-ribose) polymerase (PARP) domains of tankyrase 1 and tankyrase 2 (TNKS1/2) with reported IC50 values of 1 9 M and 0 83 M respectively By inhibiting TNKS1/2 activity JW 55 stabilizes AXIN2 a component of the -catenin destruction complex leading to enhanced degradation of -catenin and suppression of canonical Wnt/ -catenin signaling In vitro JW 55 suppresses Wnt pathway activity in colorectal cancer cells harboring APC or -catenin mutations In vivo it reduces Wnt-driven phenotypes in Xenopus embryos and diminishes polyp formation in APC-mutant mice supporting its utility as a research tool in Wnt/ -catenin signaling and cancer biology
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MEDCHEMEXPRESS LLC ICOTINIB HYDROCHLORIDE 5MG
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501873141 ICOTINIB HYDROCHLORIDE 5MG
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MEDCHEMEXPRESS LLC AST 487 5MG
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501873116 AST 487 5MG
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eMolecules 55792-50-2 | 3-(Decyloxy)aniline | MFCD00025232 | 250mg
Combi-Blocks, Inc. | 3-(Decyloxy)aniline | 250mg | 603152334 | QC-0822 | 95.000 | 55792-50-2 | MFCD00025232 | 249.398 | C16H27NO
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Medchemexpress LLC Acebilustat | 943764-99-6 | 99.7% | 481.54 | 100 MG
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Acebilustat is a leukotriene A4 hydrolase inhibitor, used as an oral antiinflammatory agent. It is safe and well tolerated in phase 1 trials. This antiinflammatory drug is in development for the treatment of CF and other diseases, acting as a potent inhibitor of the enzyme leukotriene A4 hydrolase (LTA4H), which catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a powerful chemoattractant and activator of inflammatory immune cells like neutrophils.
- Leukotriene A4 hydrolase inhibitor
- Oral antiinflammatory agent
- Safe and well tolerated in phase 1 trials
- Potent inhibitor of LTA4H
- Inhibits the formation of leukotriene B4 (LTB4)
- Being developed for the treatment of cystic fibrosis (CF) and other diseases
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MEDCHEMEXPRESS LLC PIOGLITAZONE 10MG
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501872995 PIOGLITAZONE 10MG
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Medchemexpress LLC HY-15643A 5mg Medchemexpress, LY 303511 (hydrochloride) CAS:2070014-90-1 Purity:>98%
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Medchemexpress, HY-15643A 5mg LY 303511 (hydrochloride) CAS:2070014-90-1 LY 303511 hydrochloride is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K+ currents (IC50=64.6±9.1 μM) in MIN6 insulinoma cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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